Sam won't hear anything of Blair's claim that they can only be friends. As a result, he pulls her into a kiss, and Blair can't deny the passion. Meanwhile, Troy's nerves get the best of him when Lindsay brings up Africa. Later, Lindsay decides to use Troy's celebration at his clinic as a forum to get revenge on him and Nora. At the same time, Rex tells Jessica that she needs to go to Natalie's room, so she does, and upon her arrival, Jess spots Seth and Natalie in what looks like a very compromising position. The three of them get into an argument and Jessica ultimately decides to break up with Seth. However, Seth vows to find out what Rex is hiding. Meanwhile, Chris can't handle the pain he's putting Natalie through.